Events & News

  • Paraplegics Show Gains in Study of Spinal-Cord Stimulation
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  • 07/06/2013: Chief of Neurosurgery at SFGH Describes Spine Injuries of Patients in Flight 214 Plane Crash
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  • 05/03/2013: The 2012 Reeve-Irvine Research Medal is awarded to Drs. Michael Beattie and Jacqueline Bresnahan
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  • 04/15/2012: Ashlyn Dyer | Presidio 10K Run
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  • 04/06/2012: Zero Tolerance for Injury Bounty
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  • 02/15/2012: Improved Emergency Treatment for Prolonged Seizures
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  • 09/21/2011: 1st in Nation to receive Joint Commission Certification in Traumatic Brain Injury
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  • 09/08/2011: Dr. Geoff Manley on ABC News
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  • 09/06/2011: Sidelined in Sports Concussions | Interview with Dr. Geoff Manley and Dr. Pratik Mukherjee
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  • 07/16/2011: 2011 Alzheimerís Association International Conference
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  • 07/10/2011: Bryan Stow's Family Has Hope Amid Uncertainty
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  • 04/17/2011: Ashlyn Dyer | Presidio 10K Run 2011
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  • 03/31/2011: Update on Traumatic Brain Injury and Stroke
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  • 03/01/2011: For Brain Injuries, A Treatment Gap
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  • 02/18/2011: The Today Show | Mysteries of the Brain
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  • 01/22/2011: What will Gifford's Recovery Involve?
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  • 12/15/2010: Jacqueline C. Bresnahan Named SAC Chair
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  • 10/25/2010: 9th Annual Neurotrauma Symposium
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  • 10/18/2010: Dr. Geoff Manley Featured on Discovery Channel's "Mythbusters"
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  • 05/19/2010: Dr. Geoff Manley Receives NIH Grant for Traumatic Brain Injury Research
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  • 04/16/2010: New Guidelines Aim to Improve Studies of Traumatic Brain Injury
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  • 08/28/2009: Alzheimer's Drug Could Delay Dementia | Dr. Susanna Rosi on ABC News
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  • 06/20/2008: Spinal Cord Repair | A Conversation with Jacqueline Bresnahan and Michael Beattie
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13th ANNUAL NEUROTRAUMA SYMPOSIUM

Please join us for the meeting of the 13th Annual Neurotrauma Symposium on June 29, 2914, which will be held in conjunction with the National Neurotrauma Society's 32nd Annual Meeting. 

Our nationally recognized faculty of experts will provide didactic training including lectures and case presentations on Traumatic Brain Injury (TBI) and Spinal Cord Injury (SCI). Discussion will include care and recovery across the continuum.  This health care provider driven conference is designed to empower the learner to incorporate evidence-based practice while providing excellence in care to the TBI and SCI patient. 

This exciting curriculum will include lectures from Susan Harkema, PhD, Rehabilitation Research Director, Kentucky Spinal Cord Injury Research Center.  Dr. Harkema is noted for her research on neuromodulation and rehabilitation after SCI. 

The program will close with perspectives of survivors of neurotrauma at the Public Lecture. 

Participants may register for the Neurotrauma Society Conference at a discounted rate from June 29-July 2, 2014. REGISTER HERE for the National Neurotrauma Society Conference.

Click HERE TO REGISTER for the 13th Annual Neurotrauma Symposium.  

Over forty years ago, Joan Irvine Smith, a well known Californian and philanthropist, played a lead roll in the establishment of what is now the
University of California at Irvine. Following Christopher Reeve’s tragic injury, and in recognition of his amazing spirit, she worked with UC
Irvine to establish a spinal cord injury research center in Christopher’s name. Starting with her lead gift of one million dollars, the Reeve Irvine
Research Institute grew to become the world-class research facility that it is today.
In 1996, the Reeve-Irvine Research Center and Joan Irvine Smith established an annual award for research in spinal cord injury. e award,
originally called the “Christopher Reeve Research Medal”, with Christopher’s blessing became the “Reeve-Irvine Research Medal” in 2003.
e Reeve-Irvine Research Medal recognizes an individual, or individuals, who have made highly meritorious scientic contributions in the area
of spinal cord repair, and whose research has stood the test of time and scrutiny. e medal includes a $50,000 cash award generously provided
by Joan Irvine Smith and the Athalie R. Clarke Foundation. eir kindness has made it possible to continue to recognize the work of pioneering
investigators whose work has brought us closer to cures for aictions aecting the spinal cord. Between 1996 and 2012 twenty one
exceptional researchers have received this prestigious award.
e 2012 Reeve-Irvine Research Medal is awarded to Drs. Michael Beattie
and Jacqueline Bresnahan for critical contributions to promoting repair
of the damaged spinal cord and recovery of function.Over forty years ago, Joan Irvine Smith, a well known Californian and philanthropist, played a lead roll in the establishment of what is now the
University of California at Irvine. Following Christopher Reeve’s tragic injury, and in recognition of his amazing spirit, she worked with UC
Irvine to establish a spinal cord injury research center in Christopher’s name. Starting with her lead gift of one million dollars, the Reeve Irvine
Research Institute grew to become the world-class research facility that it is today.
In 1996, the Reeve-Irvine Research Center and Joan Irvine Smith established an annual award for research in spinal cord injury. e award,
originally called the “Christopher Reeve Research Medal”, with Christopher’s blessing became the “Reeve-Irvine Research Medal” in 2003.
e Reeve-Irvine Research Medal recognizes an individual, or individuals, who have made highly meritorious scientic contributions in the area
of spinal cord repair, and whose research has stood the test of time and scrutiny. e medal includes a $50,000 cash award generously provided
by Joan Irvine Smith and the Athalie R. Clarke Foundation. eir kindness has made it possible to continue to recognize the work of pioneering
investigators whose work has brought us closer to cures for aictions aecting the spinal cord. Between 1996 and 2012 twenty one
exceptional researchers have received this prestigious award.
e 2012 Reeve-Irvine Research Medal is awarded to Drs. Michael Beattie
and Jacqueline Bresnahan for critical contributions to promoting repair
of the damaged spinal cord and recovery of function.Over forty years ago, Joan Irvine Smith, a well known Californian and philanthropist, played a lead roll in the establishment of what is now theUniversity of California at Irvine. Following Christopher Reeve’s tragic injury, and in recognition of his amazing spirit, she worked with UCIrvine to establish a spinal cord injury research center in Christopher’s name. Starting with her lead gift of one million dollars, the Reeve IrvineResearch Institute grew to become the world-class research facility that it is today.In 1996, the Reeve-Irvine Research Center and Joan Irvine Smith established an annual award for research in spinal cord injury. e award,originally called the “Christopher Reeve Research Medal”, with Christopher’s blessing became the “Reeve-Irvine Research Medal” in 2003.e Reeve-Irvine Research Medal recognizes an individual, or individuals, who have made highly meritorious scientic contributions in the areaof spinal cord repair, and whose research has stood the test of time and scrutiny. e medal includes a $50,000 cash award generously providedby Joan Irvine Smith and the Athalie R. Clarke Foundation. eir kindness has made it possible to continue to recognize the work of pioneeringinvestigators whose work has brought us closer to cures for aictions aecting the spinal cord. Between 1996 and 2012 twenty oneexceptional researchers have received this prestigious award.e 2012 Reeve-Irvine Research Medal is awarded to Drs. Michael Beattieand Jacqueline Bresnahan for critical contributions to promoting repairof the damaged spinal cord and recovery of function.                         

HOW TO HELP

YOU CAN MAKE A DIFFERENCE IN THIS SILENT EPIDEMIC!

GIVE TO THE BRAIN AND SPINAL INJURY CENTER NOW!

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Traumatic Brain Injury Research Advances with $18.8M NIH Award

UCSF to Administer Major Award, Part of Large International Research Collaboration

By Jeffrey Norris on October 22, 2013

The National Institutes of Health is awarding $18.8 million over five years to support worldwide research on concussion and traumatic brain injury.

The NIH award, part of one of the largest international research collaborations ever coordinated by funding agencies, will be administered through UC San Francisco.

The award supports a team of U.S. researchers at more than 20 institutions throughout the country who are participating in the International Traumatic Brain Injury (InTBIR) Initiative, a collaborative effort of the European Commission, the Canadian Institutes of Health Research (CIHR), the National Institutes of Health (NIH) and the U.S. Department of Defense (DOD).

Although the potential long-term harms due to concussions and blows to the head have gained more attention recently – due in part to media coverage of the experiences of athletes and of soldiers returning from the Middle East – traumatic brain injuries, or TBI, that results from automobile crashes or other common accidents impacts many more people.

Many of those who are affected by TBI are never diagnosed, according to UCSF neurosurgeonGeoffrey Manley, MD, PhD, a principal investigator for the grant who will serve as the U.S. research team’s primary liaison to the NIH, and the chief of neurosurgery at the UCSF-affiliated San Francisco General Hospital, a Level-1 trauma centerSFGH was the first medical center in the nation to achieve certification from the Joint Commission for the treatment of TBI.

The U.S. Centers for Disease Control and Prevention estimates that 2 percent of the U.S. population now lives with TBI-caused disabilities, at an annual cost of about $77 billion.

“Each year in the United States, at least 1.7 million people seek medical attention for TBI,” Manley said. “It is a contributing factor in a third of all injury-related deaths.”

In the work funded by the NIH grant – which also is supported by contributions from the private sector and from the nonprofit One Mind for Research – the researchers aim to refine and improve diagnosis and treatment of TBI, which often has insidious health effects, but which frequently is undiagnosed, misdiagnosed, inadequately understood and undertreated, according to Manley.

New Approach to Lead to Patient-Specific Treatments

“After three decades of failed clinical trials, a new approach is needed,” Manley said. “We expect that our approach will permit researchers to better characterize and stratify patients, will allow meaningful comparisons of treatments and outcomes, and will improve the next generation of clinical trials. The work will advance our understanding of TBI and lead to more effective, patient-specific treatments.”

Geoffrey Manley, MD, PhD

Since 2009, Manley and Pratik Mukherjee, MD, PhD, a professor of radiology and biomedical imaging at UCSF, have helped lay the groundwork for the continuing TBI research by leading the NIH-funded TRACK-TBI project, through which they and their research collaborators have demonstrated the value of gathering common data across research sites, including a standardized approach to imaging, clinical data, bio-specimens, and tracking outcomes.

Already, TRACK-TBI researchers have made progress toward more useful classification and prognosis of TBI.

Earlier this year, they reported that cases of concussion, or TBI that are classified as “mild” by standard criteria but that show abnormalities on early magnetic resonance imaging (MRI) scans, are much more likely to have worse outcomes three months after the scan in comparison to cases in which scans reveal no abnormalities. Furthermore, the researchers found that elevated blood levels of a protein released during brain injury was associated with the likelihood of an abnormal CT scan.

The new NIH award funds a continuation and expansion of TRACK-TBI. Among the goals is the creation of a widely accessible, comprehensive “TBI information commons” to integrate clinical, imaging, proteomic, genomic and outcome biomarkers from subjects across the age and injury spectra. Another goal is to establish the value of biomarkers that will improve classification of TBI and better optimize selection and assignment of patients for clinical trials.

The researchers also aim to evaluate measures to assess patient outcomes across all phases of recovery and at all levels of TBI severity, to determine which tests, treatments, and services are effective and appropriate – depending on the nature of TBI in particular patients.

In addition to Manley and Mukherjee, principal investigators for the newly funded project include Claudia Robertson, MD, Baylor College of Medicine; Joseph Giacino, PhD, Harvard University; Ramon Diaz-Arrastia, MD, PhD, Uniformed Services University of the Health Sciences; David Okonkwo, MD, PhD, University of Pittsburgh; and Nancy Temkin, PhD, University of Washington. Each of these leading experts has worked in the TBI field for two decades or more.

“The principal investigators bring expertise in neurosurgery, neurology, neuroradiology, critical care medicine, rehabilitation medicine, neuropsychology and biostatistics, all of which are essential and do not reside in any single individual,” Manley said.

Complete list of TRACK-TBI PIs, Core Leaders, Study Site Leader and Co-Investigators: http://www.brainandspinalinjury.org/maint/files/UCSF-BASIC-PDF-qurptv.pdf

International Funding and Collaboration

TRACK-TBI clinical enrollment sites throughout the United States will enroll 3,000 patients across the spectrum of mild to severe brain injuries. Clinical, imaging, proteomic, genomic and clinical outcome databases will be linked into a shared platform that will promote a model for collaboration among scientists within InTBIR and elsewhere.

Geoffrey Manley, MD, PhD, left, works with members of the surgical team at San

Francisco General Hospital and Trauma Center.

In addition to the U.S. award, the European Commission, the executive body of the European Union, has awarded €35.2 million to fund the Collaborative European NeuroTrauma Effectiveness-TBI (CENTER-TBI) consortium, also part of the InTBIR. This project will collect data in over 5,000 patients across Europe, where 38 scientific institutes and more than 60 hospitals will participate.

In Canada, CIHR and its national partners also have made a multimillion dollar investment in TBI research, the details of which will be formally announced in the near future.

The InTBIR Scientific Advisory Committee met in Vancouver, British Columbia, on Oct. 17-18, and awardees from all three jurisdictions (EU, USA, Canada) now are aligning efforts to share resources and collaborate on strategies for achieving the InTBIR goals.

UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. It includes top-ranked graduate schools of dentistry, medicine, nursing and pharmacy, a graduate division with nationally renowned programs in basic biomedical, translational and population sciences, as well as a preeminent biomedical research enterprise and two top-ranked hospitals, UCSF Medical Center and UCSF Benioff Children’s Hospital.

 

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FREE WEBINAR: ICP MONITORING: STANDARDS, CONTROVERSIES AND TRENDS

Webinar dealing with the current standards, controversies, and clinical implications for monitoring Intracranial Pressure (ICP) in Traumatic Brain Injury (TBI) patients
Consultants: Geoffrey T Manley, Randall Matthew Chesnut, Jamshid Ghjar, Claude Hemphill
Publication Year: 2013

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1st IN THE NATION TO RECEIVE JOINT COMMISSION CERTIFICATION IN TRAUMATIC BRAIN INJURY!

The Brain and Spinal Injury Center (BASIC) at San Francisco General Hospital and Trauma Center is proud to announce DISEASE-SPECIFIC CERTIFICATION IN TRAUMATIC BRAIN INJURY IN ACUTE CARE FROM THE JOINT COMMISSION!  

MAYOR LEE'S PRESS RELEASE

This is a tribute to all of the hard work in clinical practice and research performed at SFGH. The program would not be successful without the collaboration between nursing, rehabilitative services, social services, and hospital administration. It truly takes a village! Congratulations to all!!

Brain and Spinal Injury Center Progress Report 2005-2010

Geoff Manley, MD PhDClaude Hemphill, MD MAS, and Michael Beattie, PhD