learning and memory
Physical Therapy and Rehabilitation Science, Neurological Surgery
Principal Investigators
Susanna Rosi
Laboratory members
William Levy
Ryan Ferguson
Recent Laboratory Members
Heather L Milliken
Laboratory Mission Statement
Our long term goal is to understand how the presence of activated microglia affects learning and memory. This is of critical importance for the development of strategies to prevent cognitive impairments associated with brain injury and neuroinflammatory-related neurodegenerative disease
General overview
In my laboratory we study in vivo how local neuroinflammation (induced by irradiation or LPS infusion) disrupts activity patterns associated with synaptic plasticity and memory consolidation and contributes to the cognitive dysfunction associated with the initial stages of neurodegenerative diseases and neuroinflammatory-related disorders.
Areas of focus
glia modulation upon neuronal activity during synaptic plasticity and memory consolidation.
- Arc (activity regulated cytoskeleton-associated protein) is a good marker of synaptic plasticity because it is induced by learning and is essential for memory consolidation.TNFα, NMDAR, TNFα-inhibitors
- stability of hippocampal network during chronic neuroinflammation and treatment with NMDAR antagonistsBrain Irradiation and altered synaptic plasticity and memory.New born neurons integration in hippocampal network during chronic neuroinflammation. Information processing in the hippocampus (input and output in the entorhinal cortex-dentate-hippocampal system).
Funding and Contributors
Current:
Start Up money from the School of Medicine,
Academic Senate Individual Investigator
UCSF Academic Senate Committee on Research.
REAC grant
Collaborators
C.A. Barnes, Ph.D. Regents' Professor, Psychology and Neurology
Director, Evelyn F. McKnight Brain Institute
Evelyn F. McKnight Chair for Learning and Memory in Aging, University of Arizona, Tucson, AZ
Victor Ramirez Amaya, PhD. Assistant Professor, Instituto de Neurobiologia, Univercidad Nacional Autonoma de Mexico, Queretaro, Mexico.
Nigel Greig, PhD. Senior Investigator, National Institute of Health, Drug Design and Development Section, Laboratory of Neurosciences, NIA
Gerontology Research Center, Baltimore, MD
Almira Vazdarjanova PhD. Assistant professor, Department of Neurology
Center for Synapses and Cognitive Neuroscience Medical Collage of Georgia, Augusta GA.
Selected Publications
Rosi S, V Ramirez-Amaya, B Hauss- Wegrzyniak, Wenk GL. (2004) Chronic brain inflammation leads to a decline in hippocampal NMDA-R1 receptors. Journal of Neuroinflammation, 12-18
Ramirez-Amaya, Vazdarjanova A, Mikael D, Rosi S, Worley PF, Barnes CA. (2005)
Coordinate Arc mRNA and protein expression in the Neuronal networks activated by spatial exploration. Journal of Neuroscience, 25 (7) 1761-1768.
Rosi S, Ramirez-Amaya V, Vazdarjanova A, Worley PF, Barnes CA, Wenk GL. (2005) Neuroinflammation alter the pattern of behaviorally induced Arc in the hippocampus. Journal of Neuroscience, 25(3): 723-731
Rosi S, Pert CB, McGann-Gramling and Wenk GL. (2005) CCR5 Chemokine Receptor Antagonist regulates microglia and astrocytes activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's disease. Neuroscience, 134, (2):671-6
Vazdarjanova A, Ramirez-Amaya V, Insel N, Plummer T, Rosi S, Mikhael D, Worley PF Guzowski JF, Barnes CA. Behavior induces Arc a plasticity-related immediate-early gene in the principal excitatory and inhibitory CAMKII-positive neurons. J Comp Neurol. 2006 Sep 20;498(3):317-29
Marchalant Y, Rosi S, Wenk GL. Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a neuroinflammation rat model of Alzheimer disease. Neuroscience. December 15,
Rosi S, Vazdarjanova A, Ramirez-Amaya V, Worley PF, Barnes CA, Wenk GL.
Memantine reduces the consequences of chronic neuroinflammation and restores the hippocampal pattern of behaviorally-induced Arc expression. Neuroscience. 2006 Nov 3;142(4):1303-15
Marchalant Y, Rosi S, Wenk GL. (2007). Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a neuroinflammation rat model of Alzheimer disease. Neuroscience. 144(4):1516-22
Rola R, Zou Y, Huang TT, Fishman K, Baure K, Rosi S, Milliken H, Limoli CL, Fike JL. (2007). Lack of EC-SOD in the Microenvironment Impacts Radiation-Induced Changes in Neurogenesis. Free Radicals in Biol. & Med. 42(8):1133-45
Andres-Mach M, Rosi S, Rola R, Nalin G, Fike JF. (2007) Radiation Effects on Neurogenic Regions in the Mammalian Forebrain. Future Neurology. Vol. 2, No. 6, Pages 647-659
American Medical Association AMAI Guidelines for Medical & Health Information Sites on the Internet