Chronic Neuroinflammation, learning and memory
Assistant Professor in Residence
Susanna Rosi, Ph. D. UCSF
Degree
PhD, University of Florence - Florence, Italy
In the News
Susanna Rosi, Ph.D. investigates Alzheimer's drug that could delay dementia. Click Here
Work Experience
Postdoctoral Research Associate in the department of Neural System Memory and Aging at the University of Arizona under the guidance of Drs. Gary Wenk and Carol Barnes (2002-2006) studying chronic neuroinflammaton and memory; identifying potential therapeutic targets for the treatment of neuroinflammatory-associated diseases such as Alzheimer's.
Area of Expertise
Alzheimer’s disease, chronic neuroinflammation, hippocampus, neurodegeneration, neuron-glia communication, activated microglia, immediate early gene, synaptic plasticity, cognitive impairment, spatial memory consolidation, anti-inflammatory drugs, NMDAR-antagonists.
Research
Dr. Rosi investigates how neuroinflammation alters the neurobiological bases of learning and memory. She is studying the biology of microglial and astroglial activation in vivo to gain further insight into its role in brain pathology. Her long-term research goal is to use a multidisciplinary approach to understand how neuroinflammation alters the ensemble dynamics in the network of brain structures that undergo plasticity. Her main question is to understand the communication between neurons and altered glial and how glial presence affects neuronal function; how activated glia could modulate neuronal activity, and how these two interconnected systems interact with each other to produce the cognitive dysfunction characteristic of many neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, HIV dementia and autism.
Her focus is to understand the molecular mechanisms responsible for inflammation-associated dysfunction and damage in the CNS with the final goal of identifying potential therapeutic targets for the treatment of brain injury and neuroinflammatory-related neurodegenerative disease. To read more go to Dr. Rosi's Research Content provided by UCSF Brain & Spinal Injury Center Last updated June 9, 2008 10:43 AM
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